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醫(yī)學(xué)論文范文:環(huán)磷腺苷葡胺聯(lián)合參麥治療支氣管哮喘療效觀察
【摘要】 目的 探討環(huán)磷腺苷葡胺聯(lián)合參麥治療支氣管哮喘的臨床療效。方法 100例支氣管哮喘患者隨機(jī)分為研究組和對(duì)照組，每組50例，研究組在常規(guī)治療基礎(chǔ)上加用環(huán)磷腺苷葡胺150 mg和參麥注射液40 ml，1次/d，連用14 d，監(jiān)測(cè)2組的癥狀控制時(shí)間、肺通氣功能和血?dú)夥治�。流式�?xì)胞儀檢測(cè)外周血中T細(xì)胞亞群CD4、CD8、CD4/CD8、CD69、CD+3T淋巴細(xì)胞、CD+69CD+4T淋巴細(xì)胞水平。結(jié)果 研究組治療后VC、FEV1、PEF高于對(duì)照組(P<0.05)，研究組PaO2增加值和PaCO2下降值高于對(duì)照組(P<0.05);研究組患者治療后CD4、CD4/CD8、CD69CD+3T淋巴細(xì)胞和CD69CD+4T淋巴細(xì)胞低于對(duì)照組(P<0.05)，CD8高于對(duì)照組(P<0.05)。 結(jié)論 環(huán)磷腺苷葡胺聯(lián)合參麥治療支氣管哮喘有顯著療效，且能增加支氣管哮喘患者的免疫功能。
【關(guān)鍵詞】 環(huán)磷腺苷葡胺;參麥注射液;哮喘;治療效果
Therapeutic effects of MCAMP combined with shenmai injection on bronchial asthma YANG Wei, TANG Jihong, WANG Xiongbiao. Department of Respiratory,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China
【Abstract】 Objective To investigate the therapeutic effect of MCAMP combined with shenmai injection on asthma.Methods 100 patients with asthma were randomly divided into the research group and the control group, each group had 50 cases. The patients in control group were treated with routine western medicine, while the patients in research group,based on the same therapy as control group,were treated with MCAMP 150mg a day and Shenmai injection 40ml a day infused intravenously for 14 days. The lung function, blood gas and T cell levels (CD4,CD8,CD4/CD8, CD69CD+3 and CD69CD+4) were measured for both groups.Results In research group after treatment the VC increased to (426±123)ml,the FEVl increased to (264±55)ml,the PEF increased to (0.8±0.3)L/s, the PaO2 increased to (+3.8±1.5)kPa, the PaCO2 increased to (-3.10±1.21)kPa and CD8 increased to (29.41±7.32)%.All of the seven parameters were significantly higher than those in control group[ (311±146)ml, (195±52)ml,(0.5±0.3)L/s,(+2.23±1.26)kPa,(-2.0±1.0)kPa,(26±7)respectively](P<0.05).The levels of CD4,CD4/CD8,CD69CD+3 and CD69CD+4 in research group [(44±5)%,(1.41±0.09),(8.2±2.4)%,(3.5+1.9)% respectively] were significantly reduced, as compared with those in control group [(49±6)%,(1.91±0.29)%,(9.9±2.5)%,(6.5±2.2)%](P<0.05). Conclusion MCAMP combined with Shenmai injection is effective in treating bronchial asthma,which can improve the immunity function of patients醫(yī).學(xué)全.在.線網(wǎng)站m.gydjdsj.org.cn.
【Key words】 MCAMP; shenmai; asthma; effect
