南京大學(xué)醫(yī)學(xué)院杰青高翔簡介

姓名：高翔
研究方向：細(xì)胞生物學(xué)、發(fā)育生物學(xué)、小鼠遺傳學(xué)
聯(lián)系方式（Email)： gaoxiang@nju.edu.cn
個人簡介：
1985年于南京大學(xué)生物系獲動物學(xué)學(xué)士學(xué)位，1988于南京大學(xué)生物化學(xué)系獲蛋白質(zhì)化學(xué)碩士學(xué)位，1994年獲美國Thomas Jeferson大學(xué)發(fā)育生物學(xué)與解剖學(xué)博士學(xué)位m.gydjdsj.org.cn，1994年至1997年先后在美國Roche分子生物學(xué)研究所和Jackson實驗室做博士后研究。1997年至2000年任美國北卡大學(xué)神經(jīng)科學(xué)中心研究助理。2000年3月受聘為南京大學(xué)教授，2001年受聘為博士生導(dǎo)師及教育部長江獎勵計劃特聘教授�，F(xiàn)為國家遺傳工程小鼠資源庫主任，南京大學(xué)模式動物研究所所長,南京大學(xué)醫(yī)學(xué)院副院長。
代表性成果（專業(yè)成果、學(xué)術(shù)論文、學(xué)術(shù)專著等)：
部分論文列表：
1. Zhao J, Ding J, Li YQ, Ren KQ, Sha JH, Zhu MS, *Gao X (2009) HnRNP U mediates the long-range regulation of Shh expression during limb development. Hum Mol Genet. in press
2. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y (2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. In press
3. Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, *Gao X, *He L (2009) Sclerostin mediates bone response to mechanical unloading via antagonizing Wnt/b-catenin signaling. J Bone Miner Res, in press
4. Ding J, Gao Y, Zhao J, Yan H, Guo SY, Zhang QX, Li LS, *Gao X（2009)Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating GLP-1 in mice. Endocrinology, in press
5. Wen JH, Chen YY, Song SJ, Ding J, Gao Y, Hu QK, Feng RP, Liu YZ, Ren GC, Zhang CY, Hong TP, *Gao X, and *Li LS  (2009) Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia, 52(3):504-13.
6. Wang X, Zhang Y, Xiao G, Gao X, Liu XL (2009) c-Fos enhances survival of thymocytes during positive selection by upregulating Bcl-2.  Cell Res. 19:340-7m.gydjdsj.org.cn
7. Liu ZP, Zhang CL, Li Y, Wu ZY, Qian F, Yang XL, He WJ, Gao X, Guo Z (2009) A Zn2+ fluorescent sensor derived from 2-(pyridin-2-yl)benzoimidazole with ratiometric sensing potential. Organic letters 11:795-8
8. Qian F, Zhang CL, Zhang Y, He WJ, Gao X, Hu P, Guo ZJ (2009) Visible light excitable Zn2+ fluorescent sensor derived from an intramolecular charge transfer fluorophore and its in vitro and in vivo application. Journal of the American Chemical Society 131:1460-8
9. Zhang YF, Li H, Wang XM, Gao X, Liu XL (2009) Regulation of T cell development and activation by creatine kinase B. PLoS ONE 4:e5000
10. Chen H, Jin H, Du CY, Gu PY, Wang CY, Zhang QX, Gao X（2008)Establishment of transgenic mice expressing SV40T in parietal cells. Acta Anatomica Sinica 39: 699-702
11. Ding XF, Luo C, Ren KQ, Zhang J, Zhou JL, Hu X, Liu RS, Wang Y, *Gao X, *Zhang J (2008)  Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions. DNA and Cell Biology 27: 257-265

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