綜上所述,ET1、VEGF、HIFI在PHG的發(fā)生、發(fā)展過程發(fā)揮著重要作用,為PHG的防治提供了重要的理論依據(jù)。
【參考文獻(xiàn)】
1 黃自平,梁擴(kuò)寰.門脈高壓癥患者的胃黏膜病變.中華消化雜志,1988,27:210213.
2 趙永忠,王波,王天才,等.血管內(nèi)皮生長因子在大鼠門脈高壓性胃病發(fā)病機(jī)制中的作用.華中科技大學(xué)學(xué)報(bào)(醫(yī)學(xué)版),2003,32:163165.
3 Brat DJ,Kuar B,Van Meir EG.Genetic modulation of hypoxia induced gene expression and angiogenesis:relevance to brain tumors.Front Biosei,2003,8:d100106.
4 ejudoMartin P,MoralesRuiz M,Ros J,et al.Hypoxia is an inducer of vasodilator agents in peritoneal mucrophages of cirrhotic patients.He Patology,2002,36:11721179.
5 Tipoe GL.Fung ML. Expression of HIF1 lalpha,VEGF and VEGF receptors in the carotid body of chronically hypoxia rat.Respir Physiol Neurobio,2003,138:143154醫(yī).學(xué)全.在.線網(wǎng)站m.gydjdsj.org.cn.
6 Pufe T,Lemke A,Kurz B,et al.Mechanical overload induces VEGF in cartilage discs va hypoxiainducible factor.Am J Pathol,2004,164:185192.
7 Buchler P,Reber HA,Buchler Mw,et al.Antiangiogenic activity of genistein in Pancreatic carcinoma cells is mediated by the inhibition of hypoxiainducible factor1 and the down regulation of VEGF gene expression.Cancer,2004,100:201210.